Also shown are the casino floor size in square feet and the miles from Birmingham with drive time. This guide has reviews on the top casinos near Birmingham AL. Also the adjacent state of Mississippi has casinos within driving distance. All are near I-65 which runs North to South through the center of the state. Alabama currently has five casinos and most are located near the four largest cities Birmingham, Huntsville, Mobile and Montgomery. This guide has reviews on the top casinos near Birmingham, Alabama.